Detalhe da pesquisa
1.
Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2.
PLoS Pathog
; 19(8): e1011328, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37549173
2.
A phase 1 trial of AP30663, a KCa2 channel inhibitor in development for conversion of atrial fibrillation.
Br J Clin Pharmacol
; 90(4): 1027-1035, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-37990600
3.
Increased Density of Endogenous Adenosine A2A Receptors in Atrial Fibrillation: From Cellular and Porcine Models to Human Patients.
Int J Mol Sci
; 24(4)2023 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36835078
4.
Effective termination of atrial fibrillation by SK channel inhibition is associated with a sudden organization of fibrillatory conduction.
Europace
; 23(11): 1847-1859, 2021 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34080619
5.
Quantitative proteomics characterization of acutely isolated primary adult rat cardiomyocytes and fibroblasts.
J Mol Cell Cardiol
; 143: 63-70, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32325152
6.
Multiple genetic variations in sodium channel subunits in a case of sudden infant death syndrome.
Pacing Clin Electrophysiol
; 41(6): 620-626, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29572929
7.
Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel.
Proc Natl Acad Sci U S A
; 112(18): 5714-9, 2015 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25901329
8.
Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium.
J Cardiovasc Pharmacol
; 66(2): 165-76, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25856531
9.
Cardiac ion channels and mechanisms for protection against atrial fibrillation.
Rev Physiol Biochem Pharmacol
; 162: 1-58, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-21987061
10.
Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval.
EBioMedicine
; 89: 104459, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36796231
11.
Attenuated ventricular ß-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure.
J Cardiovasc Pharmacol
; 59(2): 142-50, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21992969
12.
Whole-Exome Sequencing Implicates Neuronal Calcium Channel with Familial Atrial Fibrillation.
Front Genet
; 13: 806429, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35154276
13.
The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na(+)/H(+) exchanger NHE1.
Cell Physiol Biochem
; 28(1): 13-24, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21865844
14.
Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits.
J Cardiovasc Pharmacol
; 57(2): 223-30, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21135701
15.
Small conductance calcium activated K+ channel inhibitor decreases stretch induced vulnerability to atrial fibrillation.
Int J Cardiol Heart Vasc
; 37: 100898, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34746364
16.
Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2.
Commun Biol
; 4(1): 1347, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34853399
17.
Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation.
Front Physiol
; 11: 493, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32595514
18.
Inhibition of KCa2 Channels Decreased the Risk of Ventricular Arrhythmia in the Guinea Pig Heart During Induced Hypokalemia.
Front Pharmacol
; 11: 749, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32508659
19.
Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction.
Front Pharmacol
; 11: 556, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32435191
20.
The KCa2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs.
Front Pharmacol
; 11: 159, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32180722